NAD+ & B12 pen: Synedica pre-filled pen, 1,000 mg NAD+ and 4,000 mcg B12

What is in the NAD+ & B12 pen?

This is the Synedica NAD+ & B12 pen, supplied sealed and unopened exactly as it leaves the manufacturer. Each box contains one pre-filled multi-use pen holding 1,000 mg of NAD+ (nicotinamide adenine dinucleotide) together with 4,000 mcg of vitamin B12, twelve disposable pen needles, and the manufacturer's leaflet. The pen is a cartridge-and-dial format: the solution is already prepared, so unlike the lyophilised vials elsewhere on this site there is nothing to reconstitute and no diluent to buy. It is the nad plus and B12 combination that appears in searches for a nad pen, an nad+ pen UK stock, and nad+ 1000mg, and we supply it strictly as a laboratory reagent for research use.

Because it is a third-party finished product, the specification is the manufacturer's rather than our own lot testing: Synedica's batch number is printed on the pen and the box, and the batch certificate is available on request. We do not open, repackage or relabel pens, and the manufacturer's packaging and leaflet are supplied as received and do not form part of our product description.

What is NAD+?

What is NAD+? Nicotinamide adenine dinucleotide is a coenzyme present in every living cell. It exists in two forms, oxidised (NAD+) and reduced (NADH), and cycles between them as it carries electrons in the reactions that turn nutrients into usable energy, which is why it sits at the centre of glycolysis, the citric acid cycle and mitochondrial respiration. Beyond its redox role, NAD+ is consumed as a substrate by three families of enzymes that have made it one of the most studied molecules in ageing biology: the sirtuins (SIRT1 to SIRT7), which regulate gene expression and mitochondrial function; the PARPs, which repair DNA; and CD38, an NAD+-consuming enzyme whose activity rises with age.

The finding that cellular and tissue NAD+ levels fall substantially with age, reported in rodents and in human tissue samples, has driven a large research programme into restoring it: through precursors such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), through direct NAD+ administration in animal models, and through inhibition of CD38. That literature is what a nad+ research reagent is for. It is often listed by vendors as an NAD+ peptide; strictly it is a dinucleotide coenzyme rather than a peptide, but the term has stuck. It is not a description of what this pen does in a person; NAD+ has no marketing authorisation as a medicine in the UK for any indication.

What is vitamin B12, and why is it paired with NAD+?

Vitamin B12 (cobalamin) is a cobalt-containing vitamin and the cofactor for two enzymes: methionine synthase, which regenerates methionine from homocysteine and feeds the methylation cycle, and methylmalonyl-CoA mutase in mitochondrial fatty-acid and amino-acid metabolism. Its research interest alongside NAD+ comes from the overlap between one-carbon metabolism and NAD+ metabolism: the salvage pathway that recycles nicotinamide back to NAD+ consumes methyl groups, and both systems converge on mitochondrial function. Manufacturers pair the two for that reason; whether the pairing has any additive effect is not established in any controlled study, and the combination is supplied here for research into both compounds, not on the basis of any claim about the pair.

NAD+ pen versus NAD+ vial

The two formats on the market are a lyophilised NAD+ vial, usually 500 mg or 1,000 mg of powder to be reconstituted, and a pre-filled pen like this one. The vial gives a laboratory control over concentration and diluent; the pen gives a fixed, manufacturer-prepared solution in a sealed cartridge with dial-metered delivery, and removes reconstitution as a variable. Searches for nad injections UK and nad+ injections generally return pen products, because that is the format most vendors now stock. The trade-off is transparency: with a vial we test each lot ourselves and publish the certificate; with a finished pen the analytical data is the manufacturer's. That is why this listing carries Synedica's name and batch certificate rather than our own laboratory's report.

NAD+ vs NMN and other precursors

NAD+ vs NMN is a common comparison. NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) are precursors: the cell converts them into NAD+ through the salvage pathway, and they are sold as oral supplements. NAD+ itself is the finished coenzyme. In cell-culture and animal work the distinction matters because the precursors depend on transporter and enzyme availability in the tissue studied, whereas NAD+ supplied directly bypasses those steps; in oral use the intact NAD+ molecule is largely broken down in the gut, which is why NAD+ products for research are supplied as solutions rather than tablets. None of this is guidance for choosing anything for use in a person.

Legal and regulatory position

NAD+ and vitamin B12 are not controlled substances in the UK. Vitamin B12 for injection is a prescription-only medicine when supplied for human use, and NAD+ has no marketing authorisation as a medicine at all. This pen is therefore supplied only as a laboratory reagent for research: it is not for human or veterinary use, and we do not answer questions about administration. The manufacturer's leaflet is included in the box as received and is not our product information. Orders where correspondence indicates an intended human use are refused, as set out in our research use policy and explained in our guide to UK law.

Buying the NAD+ & B12 pen in the UK

To buy NAD+ UK researchers usually compare a handful of vendors on the same points: whether the product is the genuine manufacturer's item or a repackaged one, whether it ships from UK stock, and whether the batch is traceable. Ours is the sealed Synedica product, held in UK stock and dispatched the same day before 1pm Monday to Friday by Royal Mail Tracked 24 in an insulated pouch with a cool pack, with the batch number visible on the box. It is priced per pen, and delivery is free over £100 so every pen ships free. As a finished third-party product it does not count towards the peptide stack discount.

Contents and pricing

• NAD+ & B12 Pen 1,000mg + 4,000 mcg: £119.99. SKU NADB12-PEN.

Prices include VAT. Shipping is £4.95 by Royal Mail Tracked 24, free on orders over £100. Ships from UK stock with the lot certificate for the pen you receive.

Quality and testing

NAD+ & B12 Pen is a finished, sealed product from a third-party manufacturer (Synedica). It is supplied as received, with the manufacturer's batch number on the pen and box, and the manufacturer's batch certificate is available on request through the certificates page. We do not open, repackage or relabel pens. Specification: Manufacturer specification (Synedica); batch certificate on request.

Format and handling

NAD+ & B12 Pen is supplied ready-prepared in a sealed pen cartridge; there is nothing to reconstitute and no diluent is required. Keep it refrigerated at 2 to 8 °C, protected from light, and capped between uses. The pen, needles and leaflet are the manufacturer's and are supplied as received. Sealed: 2 to 8 °C, protected from light. Do not freeze. Keep the pen capped between uses and within the manufacturer's in-use period.

Batch traceability

Every pen and its box carry the manufacturer's printed batch number and expiry. Quote that number to support and we will send Synedica's batch certificate for it. We supply the pen sealed and do not open, re-test or relabel it, so the analytical data is the manufacturer's rather than our laboratory's.

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