MOTS-c mitochondrial peptide (40 mg vials)
Mitochondrial open reading frame of the 12S rRNA-c
A 16-amino-acid peptide encoded in mitochondrial DNA, studied as a metabolic regulator acting through AMPK.
What is MOTS-c?
MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a 16-amino-acid peptide encoded not in the nuclear genome but in mitochondrial DNA, discovered in 2015 by Changhan Lee and Pinchas Cohen's group at USC. It belongs to a small family of mitochondrial-derived peptides that act as signalling molecules between mitochondria and the nucleus. We supply the synthetic peptide at 99%+ HPLC purity in 40 mg sealed vials.
The MOTS-c peptide is supplied as a MOTS-c 40mg vial, the size that gives the best price per milligram for extended in-vitro work.
What the research covers
In mice, MOTS-c administration improved insulin sensitivity, prevented diet-induced obesity and age-related insulin resistance, and increased physical capacity, with effects mediated by AMPK activation and regulation of the folate and methionine cycles. Circulating MOTS-c falls with age in humans, and levels rise acutely after exercise. A synthetic analogue (CB4211) completed a phase 1 trial in obesity and fatty liver. MOTS-c itself has no controlled human efficacy data and is not licensed anywhere.
Buying MOTS-c in the UK
Not a controlled substance and not a licensed medicine; sold as a research chemical for laboratory use only. UK stock, lot-tested by an independent UK laboratory, same-day dispatch before 1pm. MOTS-c is less stable in solution than most peptides in our range; reconstituted material should be used within two weeks.
Sizes and pricing
- MOTS-c 40mg: £74.99 (£1.87/mg). SKU MOTSC-40.
Prices include VAT. Shipping is £4.95 by Royal Mail Tracked 24, free on orders over £100. Ships from UK stock with the lot certificate for the vial you receive.
Quality and testing
Each lot of MOTS-c is sent to an independent UK laboratory before release for identity by mass spectrometry, purity by HPLC, residual solvents and bacterial endotoxin. The lot number on the vial label matches the certificate on our certificates page, and no lot is released for sale until the certificate is in hand. Specification: ≥ 99% (HPLC), supplied as lyophilised powder, 3 ml glass vial, sealed, 40 mg per vial.
Reconstitution and handling
MOTS-c arrives as a lyophilised cake under an aluminium crimp seal. Let the vial reach room temperature before opening so that condensation does not form on the powder. Swab the stopper with an alcohol swab, draw the chosen volume of bacteriostatic water with a sterile syringe, and add it slowly down the inside wall of the vial rather than onto the powder. Swirl gently until clear; never shake, which can denature the peptide. Label the vial with the date and concentration. The peptide calculator converts vial amount and diluent volume into concentration, millilitres and U-100 syringe units for any target amount. Sealed vial: -20 °C, protected from light. Reconstituted: 2 to 8 °C, use within 2 weeks.
Lot traceability
Every MOTS-c vial carries a printed lot number and expiry. The same lot number appears on the certificate of analysis for that batch, which names the testing laboratory and the report number so it can be verified directly. If the number on your vial does not match a certificate on our site, contact support before using it. Certificates are kept online for the life of the product plus two years.
Related products
Epitalon, BPC-157, TB-500, and everything else in Longevity & Cellular or the full range. Reconstitution supplies: bacteriostatic water, insulin syringes and alcohol swabs.
Handling and storage
Sealed vial: -20 °C, protected from light. Reconstituted: 2 to 8 °C, use within 2 weeks. Keep sealed until use. Allow the vial to reach room temperature before opening to avoid condensation on the powder. Reconstitute with bacteriostatic water added slowly down the wall of the vial; do not shake. Our calculator covers the arithmetic.
Metabolic and ageing models: insulin sensitivity, exercise capacity, mitochondrial signalling and AMPK activation, mostly in mice and cell culture. Supplied here for laboratory research only.
Because its gene sits in mitochondrial DNA rather than the nuclear genome. It is one of a handful of such peptides, alongside humanin and the SHLPs.
Sealed vials at -20 °C away from light. Reconstituted at 2 to 8 °C and used within two weeks, as it degrades faster in solution than many peptides.
Yes to buy and possess. Unlicensed, research use only.
Yes, with the certificate published on the certificates page.
